Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Design, Synthesis and Antimicrobial Assay of 1-glycosyl -3-(5-phenylimino)-1, 2, 4-thiadiazolidine carbamides

Author(s): Monika R. Thakur and Shirish P. Deshmukh

1-glycosyl-3-(5-phenylimino-1,2,4-thidiazolidine) carbamides have been synthesized by the interaction of various glycosyl isocyanates with 3-amino-5-phenylimino-1, 2, 4- thiadiazolidine. Furthermore, 3-amino-5-phenylimino-1, 2, 4-thiadiazolidine have been synthesized by the oxidative cyclization of 1-amidino-3-aryl thiocarbamide. This 1- amidino 3-aryl thiocarbamide was prepared by the interaction of guanidine nitrate and phenyl isothiocyanate. The identities of these newly synthesized compounds have been established on the basis of usual chemical transformations, elemental analysis and IR, 1H NMR and Mass spectral studies. The titled compounds were screened for their antibacterial assay against human pathogenic bacteria like E. coli, S. aureus, P. vulgaris, P. aeruginosa and K. pneumonia; for antifungal assay against plant pathogenic fungi like A. flavous, S. rolfisi, F. oxysporum and R. bataticola, to get potent bioactive molecule.


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