The synthesis of new derivatives of naproxen through the prodrug strategy is an established part of drug development for the minimization of its side effects and improving its activity, and for this purpose different heterocyclic amines such as 2-aminothiazole, 2-aminobenzimidazole and 2-aminobenzothiazole were used for the synthesis of these derivatives by linking with the parent drug naproxen. After the amidation of these amines they were coupled to naproxen hydrazide. The characterization of the synthesized compounds was done by resorting to Fourier Transform Infrared Spectroscopy (FTIR) and their purity was checked by running the C, H, N and S elemental analysis while other physicochemical properties came in handy in the identification process. The anti-inflammatory activity of naproxen derivatives were evaluated in vivo by using fresh egg white induced paw edema in Wistar albino rat in which the synthesized derivatives have either superior or comparable activity to naproxen.
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