Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Design, synthesis and biological evaluation of some novel pyrazoline derivatives

Author(s): Sagar A. Jadhav, Kiran M. Kulkarni, Pramod B. Patil, Vikas R. Dhole and Shitalkumar S. Patil

Pyrazoline is dihydropyrazole, a five member heterocyclic compound containing two nitrogen atoms in adjacent positions and possessing only one endocyclic double bond. The compound of different Pyrazoline derivatives were synthesized by cyclisation of substituted chalcone derivatives in the presence of 2, 4 dintro phenyl hydrazine hydrate. All synthesized compounds were characterized by spectral analysis. All synthesized compounds screened for their anticancer activities by MTT assay.


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