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Design, synthesis and biological evaluation of some substituted sulphonyl urea/ guanidine derivatives as hypoglycemic agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Design, synthesis and biological evaluation of some substituted sulphonyl urea/ guanidine derivatives as hypoglycemic agents

Author(s): Panchal Ishan, Panigrahi Bibhuranjan, Modh Kamal and Patel CN

Design and synthesis of sulphonyl urea and guanidine derivatives as hypoglycemic agents based on the indirect molecular modeling approach by checking the superimposibility of the design molecule and reported compound n-(6-substituted-1,3- benzothiazol-2-yl)benzene sulfonamides. Synthesize compounds was characterize by TLC, UV spectra, IR spectra, Mass spectra & 1H NMR. All the synthesized compounds were subjected to OGTT to gain preliminary information regarding the anti hyperglycemic effect in normal Albino wistar rats which are chosen for the study. Glibenclamide was chosen as the standard. Comparisiton of data was performed by one wary ANOVA followed by post test, Dunnett’s multiple comparisiton tests.


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