Design and synthesis of sulphonyl urea and guanidine derivatives as hypoglycemic agents based on the indirect molecular modeling approach by checking the superimposibility of the design molecule and reported compound n-(6-substituted-1,3- benzothiazol-2-yl)benzene sulfonamides. Synthesize compounds was characterize by TLC, UV spectra, IR spectra, Mass spectra & 1H NMR. All the synthesized compounds were subjected to OGTT to gain preliminary information regarding the anti hyperglycemic effect in normal Albino wistar rats which are chosen for the study. Glibenclamide was chosen as the standard. Comparisiton of data was performed by one wary ANOVA followed by post test, Dunnett’s multiple comparisiton tests.