Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Design, synthesis and biological screening of N1-arylsulfonyl (1H-indole-2-yl)-1-(piperazinyl) methanone derivatives as 5-HT6 receptor ligands: Part I

Author(s): Ramakrishna V. S. Nirogi,Amol D. Deshpande, Ramasastri Kambhampati, Bandyala Thrinath Reddy, Jagadishu Babu Konda, B. Venugopala Rao, Gudla Parandhama, Anil K. Shinde, P. K. Dubey

The usefulness of 5-HT6 antagonists in the treatment of cognitive disorders and more recently in obesity and feeding disorders is well documented. Keeping in mind the minimum pharmacophoric requirement needed for the 5-HT6 receptor binding, a new series of N1-arylsulfonyl (1H-indole-2-yl)-1-(piperazinyl) methanone derivatives were designed, synthesized and tested for their in-vitro affinity towards the 5-HT6 receptor.


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