GET THE APP

Design, Synthesis and In vitro Antimicrobial Screening of Some Novel Hybrid Coumarinyl-azetidinone Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

ilbet

süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey

Abstract

Design, Synthesis and In vitro Antimicrobial Screening of Some Novel Hybrid Coumarinyl-azetidinone Derivatives

Author(s): Himanshu R Prajapati, Janki J Patel, Kishor H Chikhalia

In the present study, a series of novel 3-chloro-1-(5-((2-oxo-2H-chromen-4-yl)thio)-4-phenyl thiazol-2-yl)-4-substituted phenyl azetidin-2-ones (7a-j) have been efficiently synthesized in five steps by the use of acetophenone, thiourea, 4-mercapto coumarin and chloro-acetyl-chloride. The structures of all the newly synthesized analogues were characterized by 1H-NMR, 13C-NMR spectroscopy and mass analysis. All the final synthesized analogues were examined for their preliminary in vitro antibacterial activity against Gram-positive (Staphylococcus aureus and Streptococcus pyogenes) Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacteria and antifungal activity against (Candida albicans, Aspergillus niger and Aspergillus clavatus) strains by using broth dilution technique. The results of antimicrobial study revealed that some of the newly synthesized compounds exhibits potent activity against the present specific microbial strains.

Graphical Abstract

image


Full-Text PDF

rokettube brazzers

https://pmasites.com/https://casinositeleriniz.com/https://fbhesq.com/

https://paperio-live.com

wowcappadocia.com
cappadocia-hotels.com
https://babesoflondon.com/
balloon-rides.net

wormax io