Pyrimidine nucleus is an important pharmacophore in medicinal chemistry. The synthesis of novel pyrimidine derivatives remains a main focus of modern drug discovery. In the present study, eight hybridized pyrimidine derivatives were synthesized via Biginelli condensation and evaluated for their in-vitro antimicrobial activity. The antimicrobial results revealed that all the compound exhibited promising antibacterial activity and the compounds DP-3, DP-5, DP-7, DP-8 exhibited pronounced antifungal activity displaying minimal inhibitory concentration values of against bacterial strains and fungal strains compared with standard Ciprofloxacin (for bacteria) and Cotrimazole (for fungi).
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