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Design, Synthesis, Characterization and Biological Evaluation of Some Substituted Dihydropyrimidinone Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Design, Synthesis, Characterization and Biological Evaluation of Some Substituted Dihydropyrimidinone Derivatives

Author(s): Beena KP, Rajasekaran A, Manna PK, Suresh R

Pyrimidine nucleus is an important pharmacophore in medicinal chemistry. The synthesis of novel pyrimidine derivatives remains a main focus of modern drug discovery. In the present study, eight hybridized pyrimidine derivatives were synthesized via Biginelli condensation and evaluated for their in-vitro antimicrobial activity. The antimicrobial results revealed that all the compound exhibited promising antibacterial activity and the compounds DP-3, DP-5, DP-7, DP-8 exhibited pronounced antifungal activity displaying minimal inhibitory concentration values of against bacterial strains and fungal strains compared with standard Ciprofloxacin (for bacteria) and Cotrimazole (for fungi).


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