A series of N-[2(dimethylamino)-2-iminoethanimidoyl-2-phenoxyacetamide derivatives have been synthesized by reaction of Metformin, Chloroacetyl chloride and an appropriate Phenol. Structures of these compounds were established by IR, 1H NMR. All the compounds were evaluated for their Anti-diabetic activity. Fasting blood sugar level was estimated on hours 0,2,4,6 and 24 from rat tail vein using glucometer. Data was statistically analysed by Dunnett’s test. Metformin derivatives of Phenol PHE-9, PHE-5 and PHE-6 produced a time dependent decrease in blood glucose level significantly compared to Metformin. However, this study shows hypoglycaemic action of Metformin.
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