Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Design, Synthesis of New Iso-oxazoline Containing Iminothiazolidinone and its Antibacterial Activity

Author(s): Sudhakar G Patil, Deepak S Kadam, Rahul R Bagul, Navneet S Bagul, Nandini S Kotharkar

We have synthesized novel 2-(4-(3a,4,5,6,7,7a-hexahydro-4,7-methanobenzo[d]isooxazol-3-yl)phenyl) imino)-3-methylthiazolidin-4-one and its benzilidine derivatives in good yields, by clubbing substituted Isooxazoline and 4-Iminothiazolidinone. All the synthesized compounds were characterized using IR and NMR spectroscopy. The results of the characterization are in agreement with the structures of compounds and tested for its antibacterial and antifungal activity against various strains like Staphylococcus aureus (NCLM 2602), Bacillus subtilis (NCLM 2458), Escherichia coli (NCLM 2809), Aspergillus niger (NCLM 617), Rhizopus ostoyae NCLM 1299) by using antibacterial susceptibility test. All the newly synthesized compounds possess moderate to good antibacterial activity.

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