Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Design, synthesis of pyrazol-1-carbaldehyde derivatives under microwave irradiation in solvent-free conditions and their biological investigation

Author(s): Srinivasa Rao Jetti, Tanuja Kadre, Anjna Bhatewara and Shubha Jain

A new series of pyrazol-1-carbaldehydes 5(a-f) were synthesized by reacting chalcones 3(a-d) with hydrazine 4 using ion exchange resins viz. amberlite formate and amberlyst 15 DRY as reusable heterogeneous catalysts in solvent free conditions. The present methodology offers several advantages such as simple procedure with an easy work-up, shorter reaction times, and high yields. The structures of newly synthesized compounds have been established by spectral, elemental analysis and evaluated for their antioxidant, antibacterial, and antifungal activity. Some of them were found to possess significant activity, when compared to standard drugs.


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