Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Design, Synthesis, Structural Elucidation and Biological Applications of Benzohydrazide Derivatives

Author(s): Benita Sherine H, Veeramanikandan S

series of benzohydrazide derivatives plays a vital role owing to their range of biological and physiological activities. Some new benzohydrazide derivatives have been successfully prepared by the condensation reaction in the present study. The reaction has been carried out at various conditions. The synthesized compounds have characteristic functional groups in the molecules are confirmed through Fourier Transform Infra-Red (FTIR), Proton Nuclear Magnetic Resonance (1H-NMR) and Carbon 13 Nuclear Magnetic Resonance (13C-NMR). Mass spectrometry provides information pertaining to the structures and molecular weight of the some selected compounds. All the compounds were screened for their antibacterial and antifungal activity in Minimum Inhibitory Concentration (MIC) levels. The antioxidant activity of Schiff base containing benzohydrazide moiety and its derivatives were investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. Further, to exemplify the key structural features of the compounds, a molecular docking analysis was performed at Mycobacterium tuberculosis enoyl acyl carrier reductase InhA protein.


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