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Designing, Synthesis and characterization of novel Substituted pyrazol-azetidin-2-one/thiazolidin-4-one derivatives for their antimicrobial activity | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Designing, Synthesis and characterization of novel Substituted pyrazol-azetidin-2-one/thiazolidin-4-one derivatives for their antimicrobial activity

Author(s): Krishna Srivastava*, Raj Bahadur Singh, Jyoti Srivasata and Dinesh Gupta

This research work includes the synthesis of (3-hydroxy-4-methoxyphenyl)-3-((1-(5-(2-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl) ethylidene)amino)thiazolidin-4-one(VIIa-f)/3-chloro-4-(substitutedphenyl)-1-((1-(5-(2-nitrophenyl)-3-phenyl-4,5-dihydro-1H-pyrazol1yl)ethylidene) amino) azetidin-2-one(VI a-f) having a pyrazol ring, obtained from the reaction of hydrazine hydrate with chalcone along with athiazolidinone ring/azetidinonemoeity, procured after the cyclization of a schiff base by thioglycolic acid/Chloroacetyl chloride. The structure of the synthesized compounds has been established on the basis of elemental analysis, UV-Vis absorption spectroscopy, IR, 1HNMR, and mass spectral studies. The in vitro antimicrobial screening of all the novel compounds was done against S.aureus, E.coli, P.aeruginosa and B. subtilis. The activity of VIb, VIf, VId and VIIa, VIIf, VIIdVIIe compounds exhibited excellent activity while the rest showed moderate to good activity against the tested microbes.


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