Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Determination of captopril with potassium permanganate chemiluminescence system

Author(s): Fengzhen Yang, Xingang Tian, Xiaozhen Fan, Wenyu Zhang and Pengpeng Ren

Chemiluminescence (CL) emission can be generated by mixing potassium permanganate with captopril under acidic conditions. Formaldehyde can significantly enhance the CL signal. This phenomenon has been utilized to design a new flow-injection chemiluminescence method for the determination of captopril with the permanganate-formaldehyde-captopril CL system. Under the optimum experimental conditions, the proposed method has a quantitation linear range of captopril between 0.02 and 2.0μg mL-1, with a detection limit of 0.01μg mL-1 and a correlation coefficient of 0.9998. The method was applied to the determination of captopril in pharmaceutical preparations and the results were satisfactory.