Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Determination of Famotidine in Pharmaceutical Preparations by Flow Injection Spectrophotometric Method and using organic reagent (Pyro catechol)

Author(s): Sadeem S. Abid and *Rajaa M. Ali

Simple accurate and sensitive batch and flow injection spectrophotometric method was depicted for the determination of famotidine (FAM) in pharmaceutical formulation. The proposed method based on oxidative coupling reaction between famotidine and the organic reagent -pyro catechol- in the presence of ferric ammonium sulfate as oxidant agent to give the water soluble blue colored product with high absorptivity at a wavelength of 580nm.The molar ratio of FAM and pyro catechol was 1:1. The Optimum conditions and analytical parameters of batch reaction method were evaluated The linearity of spectrophotometric method was in the range of (15-450) μ with a correlation coefficient of 0.9979. The detection limit was 10.425 μ The flow injection method the linear range (100- 1500) μg. mL-1, and the detection limit 87.22μg .mL-1. The proposed method was applied successfully to the assay of famotidine in pharmaceutical preparation.


bornova escort karşıyaka escort osmangazi escort buca escort anne porno fetiş porno anal porno bartın escort burdur escort eskişehir escort escort izmir bursa escort porno escort bayan