Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Determination of formation constants and themodynamic parameters of trifluoperazine-metal complexes by potentiometric method

Author(s): Tanaji N. Bansode

The complex formation constants of Trifluoperazine with Fe (III), Cd (II), Pb (II), Cu (II) and Zn (II) metal ions have been studied by potentiometric measurements. All titrations were performed in aqueous medium at constant ionic strength (0.10 mol⋅dm−3). The complex formation constants were determined at 25.00 and 35.00 °C by different Computational Methods. The thermodynamic parameters (ΔG, ΔH and ΔS) and the thermodynamic stability constants for all of the investigated complexes were determined.