Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Determination of Primary and Functional Metabolites of Salvia argentea and Evaluation of its Leaves and Roots Antioxidant Activity

Author(s): Wafaa Tehami, Asmaa Kherraf, Wahiba Boufeldja, Mustapha Mahmoud DIF, Amira Ghislaine DRA, Bouziane Abbouni, Mohammed Benali

The objective of this work is to determine the primary metabolites and functional principles and to evaluate the antioxidant activity of silver sage Salvia argentea, an herbaceous plant growing in Algeria. Physicochemical analyzes performed for the first time revealed appreciable levels of primary metabolites. It contains for the leaves and roots, respectively, a moisture content of 9.50 ± 0.01% and 8.63 ± 0.16%, ash content of 14.68 ± 0.10% and 9.03 ± 0.04% and for the fat content a rate of 2.92 ± 0.11% and 3.94 ± 0.05%. The aerial and subterranean parts of S. argentea, have respectively contents of 10.73 ± 0.18% and 5.23 ± 0.32% of proteins. On the other hand, poverty in sugars in the roots was observed (0.15 ± 0.12%) compared to leaves (4.13 ± 0.04%). The mean polyphenol contents of leaves and roots in methanolic and aqueous extracts were 87.13 ± 0.32-55.64 ± 0.35 mg GAE/g and 71.80 0.79-48.20 0.79 mg GAE/g. The flavonoids were 59.97 ± 0.21-31.22 ± 0.49 mg CE/g and 44.16 ± 0.60-18.12 ± 0.54 mg CE/g and tannins respectively of 3.70 ± 0.09-5.58 ± 0.13 mg CE/g and 4.01 ± 0.16-5.83 ± 0.09 mg CE/g. In addition, the extracts tested showed appreciable antioxidant powers using the FRAP iron reduction method and the free radical scavenging method DPPH. The IC50s range from 45.42 ± 0.46 to 416.12 ± 0.26 μg/ml. This study indicates that S. argentea may be a potential source of antioxidants used for therapeutic purposes.


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