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Determination of the protonation constants of some chalcones [(2E)-1-(substituted-methylthiophene-2-yl)-3-(substituted-pyridinyl)prop-2-en-1-ones] by the potentiometric method in nonaqueous solvents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Determination of the protonation constants of some chalcones [(2E)-1-(substituted-methylthiophene-2-yl)-3-(substituted-pyridinyl)prop-2-en-1-ones] by the potentiometric method in nonaqueous solvents

Author(s): Fatih Đslamoğlu, Asu Usta, Đsmail Aksu and Nurettin Yaylı

Some Chalcones [(2E)-1-(Substituted-Methylthiophene-2-yl)-3-(pyridin-substituted-yl)prop- 2-en-1-ones] derivatives were titrated with tetrabutylammonium hydroxide (TBAH) in four non-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, N,N - dimethylformamide and acetonitrile ), using potentiometric method. The half neutralization potential values and the corresponding pKa values were determined for all cases.


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