Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Determination of the protonation constants of some chalcones [(2E)-1-(substituted-methylthiophene-2-yl)-3-(substituted-pyridinyl)prop-2-en-1-ones] by the potentiometric method in nonaqueous solvents
Author(s): Fatih ÃâÃÂslamoÃâßlu, Asu Usta, ÃâÃÂsmail Aksu and Nurettin YaylÃâñSome Chalcones [(2E)-1-(Substituted-Methylthiophene-2-yl)-3-(pyridin-substituted-yl)prop- 2-en-1-ones] derivatives were titrated with tetrabutylammonium hydroxide (TBAH) in four non-aqueous solvents (isopropyl alcohol, tert-butyl alcohol, N,N - dimethylformamide and acetonitrile ), using potentiometric method. The half neutralization potential values and the corresponding pKa values were determined for all cases.
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