Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


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Development and Validation of First Order Derivative Spectrophotometric Method for Simultaneous Estimation of Atorvastatin Calcium and Aspirin in Capsules

Author(s): Padmavathi Y*, Raghavendra Babu N, Ravi Kumar P, Sowmya D and Rohini K

A simple UV spectrophotometric method using first order derivative technique was developed for the simultaneous estimation of atorvastatin calcium and aspirin in capsules. The atorvastatin calcium and aspirin stock solutions were prepared in (50: 50 v/v) methanol: water and scanned in UV- region for first order derivative spectrum. The zero crossing point for atorvastatin calcium and aspirin was 243 nm and 276 nm respectively. Linearity was established over the concentration range of 6-14 μg/ml and 20-100 μg/ml for atorvastatin calcium and aspirin with correlation coefficient (r2) value 0.998 and 0.999 respectively. The method was validated according to ICH guidelines for validation parameters like accuracy, precision, limit of detection and limit of quantification. They found to be within limits. The method was successfully applied for quantitative estimation of atorvastatin calcium and aspirin in capsules.

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