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Development and validation of high performance liquid chromatographic method for the Simultaneous Estimation of Candesartan cilexetil and Hydrochlorothiazide in combined tablet dosage form | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Development and validation of high performance liquid chromatographic method for the Simultaneous Estimation of Candesartan cilexetil and Hydrochlorothiazide in combined tablet dosage form

Author(s): K. Balamuralikrishna and B. Syamasundar

A simple, sensitive and reproducible reverse phase high performance liquid chromatographic method has been developed for simultaneous estimation of Candesartan cilexetil and Hydrochlorothiazide in combined tablet dosage form. Chromatography was performed on a 250 mm x 4.6 mm, 5-μm particle size, C8 Hypersil BDS column with a 60:40 (v/v) mixture of acetonitrile and Triethylamine (0.02 %) as a mobile phase and the pH was adjusted to 5.5 with dilute o-phosphoric acid. The detection of the combined dosage form was carried out at 262 nm and a flow rate employed was 1.0 mL/min. The retention times were 2.449 and 4.895 min for Candesartan and Hydrochlorothiazide respectively. Linearity was obtained in the concentration range 50 to 150 μg/mL for Candesartan cilexetil and 75-225 μg/mL for Hydrochlorothiazide, with a correlation coefficient of 0.9999 and 0.9999. The results of the analysis were validated statistically and recovery studies confirmed the accuracy and precision of the proposed method.


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