Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Development and validation of rapid HPLC method for determination of Pregabalin in bulk drug and capsule dosage forms

Author(s): Ashu M*, Parmar S, Nagarajan K and Vijendra Singh

A simple,selective, rapid, and economical reversed phase high performance liquid chromatography(RP-HPLC)method for the determination of pregabaline in the capsule dosage form has been developed and validated.The separation and quantification were achieved on waters spherisorb 5μ ODS 24.6mm x 250mm column using a mobile phase of acetonitrile:buffer (30:70 V/V) at a flow rate of 1ml/min with detection of analyte at 210 nm. The separation was achieved within 3.1±0.3 min for pregabalin sample. Peak width was found to be 5.26s and SD was found to be 1.3152 for the sample peak . The method showed good linearity in the range of 200-800 μg/ml. The intra and inter day R.S.D ranged from 0.79-1.85% The recovery (mean ±S.D.) of low, middle and high concentrations were 100.02 ± 0.80, 100.05 ± 0.42, 100.03 ± 0.35 respectively.


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