Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Development and validation of spectrophotometric methods for quantitative estimation of Meloxicam in bulk and pharmaceutical dosage forms

Author(s): Ananth V, Venkatamahesh R, Ulaganathan C, Balaji M and Sachin Kumar Singh

Three Simple, precise and economical UV methods have been developed and validated for the quantitative for the estimation of Meloxicam in bulk and pharmaceutical dosage forms. Meloxicam has the absorbance maxima at 360 nm (Method A), and in the first order derivative spectra and second order derivative spectra, shows sharp peaks at 338 nm (Method B), 281nm (Method c) respectively. Beer’s law was found to be obeyed in the concentration range of 5-25 μg/mL for the Method A, B and C. The developed method was validated according to ICH guidelines and was found to be accurate and precise. The proposed method can be successfully applied for the estimation of Meloxicam in bulk and pharmaceutical dosage forms. Results of the analysis were validated statistically and by recovery studies.


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