Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Development and validation of uv spectrophotometric method for estimation of dexibuprofen in bulk and dosage form

Author(s): Pritesh G. Dhartarkar, Rajan V. Kalamkar, Suprit D. Saoji, Shailesh G. Ingle, Sandeep C. Atram, Madhuri D. Game.

The aim of present work is to develop and validate simple, sensitive and specific spectrophotometric method for the determination of Dexibuprofen, a non-steroidal antiinflammatory drug (NSAID) in pure form and in pharmaceutical formulations. UV spectrophotometric method, which is based on measurement of absorption at maximum wavelength in phosphate buffer pH 6.8, was found to be at 221.8 nm by using 5% methanol. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The optimum conditions for analysis of the drug were established. The drug obeyed the Beer’s law and showed good correlation. Beer’s law was obeyed in concentration range 0-60 μg/ml having line equation y = 0.046x +0.017 with correlation coefficient of 0.999. The results of analysis were validated by recovery studies. The method was found to be simple, accurate, precise, economical and robust.


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