Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Development and validation of UV spectrophotometric method for the determination of Gliclazide in tablet dosage form

Author(s): Samina A. Jamadar, Snehal P. Mulye, Poonam S. Karekar , Yogesh V. Pore, Kishor B. Burade

The article describes a simple, sensitive, rapid, accurate and precise spectrophotometric method for the estimation of gliclazide in bulk and pharmaceutical dosage forms. The wavelength maxima for gliclazide was found to be 229.5 nm with molar absorptivity of 1.4962×104l/mol/cm. Beer’s law was obeyed in the concentration range of 7-27 μg/ml. The limit of detection (LOD) and limit of quantification (LOQ) were found to be 0.31 μg/ml and 0.92 μg/ml, respectively. The percentage recovery of the drug for the proposed method ranged from 98.68-100.12% indicating no interference of the tablet excipients. The results demonstrate that proposed method is accurate, precise, and reproducible while being simple and rapid too for the determination of gliclazide in tablet dosage form.


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