Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Development and validation of UV-visible spectrophotometric method for estimation of rifapentine in bulk and dosage form

Author(s): Priyanshu Jain and Vinay Madhav Pathak

The aim of present work is to develop and validate simple, sensitive and specific spectrophotometric method for the determination of rifapentin, an anti-tubercular drug in pure form and in pharmaceutical formulations. UV-VISIBLE spectrophotometric method, which is based on measurement of absorption at maximum wavelength in 0.1N HCl, was found to be at 478 nm. The developed method was validated with respect to linearity, accuracy (recovery), precision and specificity. The optimum conditions for analysis of the drug were established. The drug obeyed the Beer’s law and showed good correlation. Beer’s law was obeyed in concentration range 5-50 μg/ml having line equation y = 0.004x + 0.024 with correlation coefficient of 0.999. The results of analysis were validated by recovery studies. The method was found to be simple, accurate, precise, economical and robust.


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