Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Development and Validation of Visible Spectrophotometric methods for the Estimation of Metolazone in Pharmaceutical Dosage Forms

Author(s): S Sandeep Kumar, Shobha Manjunath, Venkatesh Chouhan and S Appalraju

Two simple and sensitive spectrophotometric methods (A and B) have been developed for the quantitative determination of Metolazone in bulk drug and pharmaceutical Formulations. Method A is based on the oxidative coupling reaction of Metolazone with MBTH to yield a green colored chromogen exhibiting absorption maxima at 623nm and Method B is based on the reaction of Metolazone with Folin-Ciocalteu (Fc) reagent in alkaline media to yield a blue colored chromogen exhibiting absorption maximum at 725nm. Beer’s law was obeyed in the concentration range of 10-50μg/ml for methodA and 50-250μg/ml for methodB. These methods were extended to pharmaceutical formulations and there was no interference from any common excepients. The results of analysis have been validated statistically and by recovery methods.


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