Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Development and Validation of Visible Spectrophotometric methods for the Estimation of Ethamsylate in Pharmaceutical Dosage Forms

Author(s): MD Arshad, Arvind Karadi, Venugopal Darak and Sajja Appal Raju,

Two simple and economical visible spectrophotometric methods (A and B) have been developed for the quantitative determination of Ethamsylate in bulk drug and pharmaceutical dosage forms have been developed. Method A is based on the reaction of Ethamsylate with Folin-Ciocalteu (phenol’s) reagent under alkaline conditions forming a blue colored chromogen exhibits absorption maxima at 619 nm. Beer’s law was obeyed in the concentration range of 10-50μg/ml. In Method B Ethamsylate undergoes oxidation followed by complex formation reaction with 1,10 phenanthroline in presence of ferric chloride to form red coloured chromogen exhibiting absorption maximum at 510 and obeyed Beer’s law in the concentration range of 1-5 μg/ml. These methods were extended to pharmaceutical formulations and there was no interference from any common excipients. The results of analysis have been validated statistically and by recovery methods.


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