Threesimple and sensitive spectrophotometric methods (A, B and C) have been developed forthe quantitative determination of Mesalamine in bulk drug and pharmaceutical preparations.Method A, B are based on the condensation of Mesalamine with p-dimethyl aminobenzaldehyde and pdimethyl amino cinnamaldehyde to form schiff’s bases, to yield a yellow, red colored chromogen and exhibits absorption maxima at 440, 523.5 nm. Method C isbased on the reaction of Mesalamine with Folin-Ciocalteu (phenol’s) reagent under alkaline conditions forming a blue colored chromogen and exhibits absorption maxima at 616 nm. Beer’s law was obeyed inthe concentration range of 50-250, 20-100 and 10-50μg/ml for method A,B and C respectively. Thesemethods were extended to pharmaceutical formulations and there was no interference from any common excepients. The results of analysis have been validated statistically and by recoverymethods.
Select your language of interest to view the total content in your interested language