Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Development of a Validated Initial Rate Method for the Assay of Gliclazide in Drug Formulations

Author(s): Elaref Ratemia, S. K. Manirul Haquea and Habibur Rahmanb

The objective of this work was to develop a simple, sensitive and kinetics based spectrophotometric method for the determination of gliclazide in drug formulations. The method was based on the oxidation of the drug with an alkaline potassium permanganate at room temperature (25±10C). The reaction was followed spectrophotometrically by measuring the rate of change of the absorbance at 602 nm. The initial rate method was adopted for constructing the calibration curve which was linear in the concentration range of 1.5 ×10-5 M -1.85 ×10-4 M corresponding to 5.0 – 60.0 μg/mL. The limits of detection and quantitation were 0.99 and 3.03 μg/mL, respectively. Statistical comparison of the results shows excellent agreement and indicates no significant difference in accuracy and precision. The method can be used for routine quality control testing of commercial dosage forms.


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