Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Development of analytical method for Risperidone by UV Spectrophotometry using methanol as a solvent

Author(s): G.Alagumani Vasagam, A.Anton Smith, CH .Nawas, M.Sravan Kumar, A.Kottai Muthu and R.Manavalan

A simple, sensitive, specific, spectrophotometric method has been developed for the detection of Risperidone in pure form and pharmaceutical dosage forms. The optimum condition for the analysis of the drug were established. Risperidone exhibiting absorption both at 240 and 280 nm and obeyed beers law in the concentration range of 20 to 60μg/ml. The lower limit of detection was found to be 2.788 μg/ml and the limit of quantification was found to be 8.45 μg/ml. The regression equation was y = 0.0284 x and y = 0.028 x for 240 nm and 280 nm respectively. The precision of the method was found to be 1.9083 at 240 nm and 1.9583 at 280 nm against the label claim of 2 mg. The percentage recovery was found to be 2.12 ± 0.242 and 2.19 ± 0.196 for 240 nm and 280 nm respectively. The sample solution was stable up to 24 hours. The assay results were found to be in good agreement against the label claim. The proposed method was simple sensitive, precise, accurate and easy for routine quality control analysis


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