Development of furfuraldehyde formazans as potential antitubercular agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Development of furfuraldehyde formazans as potential antitubercular agents

Author(s): Vanita Saharan and Supriya Mahajan

This article envisages the development of furfuraldehyde formazans as antitubercular agents. A series of furfuraldehyde formazans were synthesized and characterized by spectral analysis. The antitubercular activity of these compounds was assessed against Mycobacterium tuberculosis (MTB) H37Rv. Four compounds, 2b, 2c, 2g and 2i showed moderate to good antitubercular activity against H37Rv. Inactivity of all these compounds against gram positive and gram negative bacteria indicated their specificity against MTB. The synthesized compounds were analyzed for ADME properties and showed potential as good oral candidates. The work identified few lead compounds that can be explored further for the development of potential antitubercular agents.


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