Development of RP-HPLC method for estimation of Olmesartan Medoxomil in tablet dosage forms | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Development of RP-HPLC method for estimation of Olmesartan Medoxomil in tablet dosage forms

Author(s): Chaitanya prasad MK, Vidyasagar G, Sambasiva Rao KRS and Ramanjeneyulu S

Reversed phase high performance liquid chromatographic method was developed and validated for the estimation of Olmesartan medoxomil in bulk and formulation. Selected mobile phase was a combination of phosphate buffer with pH adjusted at 2.8 and acetonitrile (35:65% v/v) and wavelength selected was 250 nm. Retention time of Olmesartan medoxomil was 2.591 min. Linearity of the method was found to be 50-150 μg/ml, with the regression coefficient of 0.9993. Quantification was done by calculating area of the peak and the detection limit and quantitation limit ware 0.02μg/mL and 0.09μg/mL, respectively. There was no significant difference in the intraday and inter day analysis of Olmesartan medoxomil determined for three different concentrations using this method. Present method can be applied for the determination of Olmesartan medoxomil in quality control of formulation without interference of the excipients.


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