Diabetes associated dyslipidemia: Management | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.


Diabetes associated dyslipidemia: Management

Author(s): Ramachandran Vadivelan, Dipanjan Mandal, Umasankar Payyavulla, Dhanabal Palaniswamy, Kannan Elango and Suresh Bhojraj

By the year 2030 , it is assumed that there will be more than 300 million type 2 diabetes sufferers worldwide. Diabetes is a serious vascular disease with poor prognosis, and not only a disease characterized by elevated blood glucose . One important cardiovascular risk factor in type 2 diabetic people is dyslipidaemia. This comprises low HDL-cholesterol, high serum VLDL-triglycerides, and a preponderance of small, dense LDL. Even slight elevations of LDL-cholesterol in type 2 diabetes are associated with a substantial increase in cardiovascular risk. The composition of lipid particles in diabetic dyslipidaemia is more atherogenic than in dyslipidaemia in general. Atherosclerosis is a major complication of diabetes responsible for the increased morbidity and mortality. Lowering of LDL-cholesterol is a very attractive target of lipid modifying therapy, dyslipidaemia therapies are efficacious for both LDL-cholesterol reduction and raising HDL-cholesterol might offer more improvements in coronary heart disease in type 2 diabetic people. Statins are first-line pharmacotherapy for dyslipidaemia and can also improve HDL-cholesterol levels. Combining a fibrate or niacin with statin therapy raises HDL-cholesterol more than a statin alone but might be associated with reduced tolerability and increased adverse reactions. Several new therapeutic approaches to raising HDL-cholesterol are in development, including an HDL mimetic and inhibitors of cholesteryl ester transfer protein. Dyslipidaemia therapies are efficacious for both LDLcholesterol reduction and raising HDL-cholesterol might offer further improvements in coronary heart disease (CHD) risk reduction.


Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry