Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


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Direct nuclear halogenation of deactivated aryl and N-heteroaryl amines: An overview

Author(s): Anirudha A. Waghmare, Prosenjit Bose and Hari N. Pati

Halogenated aromatic amines are versatile building blocks in organic synthesis and form an important class of bioactive molecules in pharmaceutical chemistry. An array of novel methods and reagent systems has been developed to affect its synthesis. This review presents an overview of methods used for efficient and regioselective nuclear halogenation of deactivated aryl and Nheteroaryl amines.


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