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Discovery of Clubbed Thiazolo [3,2-a]pyrimidinones as Antimicrobial Agents | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Discovery of Clubbed Thiazolo [3,2-a]pyrimidinones as Antimicrobial Agents

Author(s): Babasaheb Zine, Sunil Jadhav, Prashant Dixit, Mazahar Farooqui,

Bacterial and fungal infections represent one of the most prevalent health problems that cause functional disability, leading to lifestyle sacrifice and further complications. Upcoming needs for the clinical drugs candidates for the improvement signifies an exciting and challenging approach to improve the clinical efficacy of current drugs in the development of new therapeutic approaches. Current report reveals the synthesis of fused pyrimidinones and their evaluation against above antibacterial and antifungal therapeutic area. Out of 12 compounds reported here, many of them displayed decent antibacterial and antifungal profiles. We report herewith most prominent molecules 5d, 5e, 5f, 5g, 5h and 5i. In conclusion, 5g have been identified as the lead with the most prominent results.


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