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Dynamics of lipid peroxidation in the exhaled breath condensate in healthy people during hypo- and hyperosmolar bronchial provocation tests | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Dynamics of lipid peroxidation in the exhaled breath condensate in healthy people during hypo- and hyperosmolar bronchial provocation tests

Author(s): Eugene A. Borodin, Anna G. Prikhodko, Mikhail A. Shtarberg, Leonid G. Nahamchen, Evgeniya Yu. Afanasyeva, Victor P. Kolosov and Juliy M. Perelman

The dynamics of lipid content in the exhaled breath condensate (EBC) as well as the degree of lipid oxidation in healthy persons before and after executing of bronchial provocation tests with osmotic stimulus had been studied. Within three-days study the content of non-oxidized lipids and dien conjugates in EBC samples significantly increased. The bronchial provocation tests with hyperosmolar stimulus (inhalation of 4,5% solution of NaCL and incremental exercise) result in the decrease of lipid content in EBC while the hyposmolar one (inhalation of distilled water) leads to opposite effect. The content of diene conjugates in EBC samples after hyposmolar and hyperosmolar aerosol inhalations had been increased but was not influenced by the incremental exercise. Bronchial provocation tests did not influence the content of conjugated trienes and ketodienes in EBC. The results obtained show the influence of the osmotic stimuli on the peroxidation of airway lipids in healthy persons.


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