The objective of the current study is to develop a simple, sensitive ultraviolet absorption spectrophotometric method for the estimation of poorly water soluble drugs like Cefixime, norfloxacin, tinidazole, and metronidazole in pharmaceutical formulations and to evaluate the increased solubility of cefixime in the prepared formulation. Aqueous solubilities of these selected model drugs were enhanced to a great extent (5 to 98 fold) in distilled water, SGF and SIF along with 0.2 M phosphate buffer. The various hydrotropic agents that can be used include ammonium acetate (6M), Potassium acetate (5M),Potassium citrate (0.5 M), Sodium citrate (1.25 M) , Urea (8M). 2.0 M sodium benzoate, and the most affordable and safe solubilizing agent that has been used here ie. Sodium lauryl sulphate. The primary objective of the present investigation is to employ this solubilising agent to extract and dissolve the drugs from their dosage forms, precluding the use of costlier organic solvents. The selected λmax for Cefixime is 288 nm and Sodium lauryl sulphate did not show any absorbance at 288 nm, and therefore, no interference in the estimation is seen. The results of analysis have been validated statistically, and by recovery studies. The proposed method is new, simple, economic, accurate, safe and precise. Increasing the aqueous solubility of insoluble and slightly soluble drugs, is of major importance. Various organic solvents like methanol, chloroform, alcohol, dimethyl formamide, and benzene have been employed for the solubilization of poorly water soluble drugs for spectrophotometric estimations. Drawbacks of organic solvents include higher cost, toxicity, pollution, and error, in analysis due to volatility. In the preliminary solubility studies, it was found that there was considerable enhancement in the aqueous solubilities .