Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Effect of Crosslinking on swelling behaviour of IPN hydrogels of Guar Gum & Polyacrylamide

Author(s): Jagadish N. Hiremath, Vishalakshi B.

An IPN system comprising of guar gum and polyacrylamide has been made in aqueous medium. Polymerization of acrylamide has been achieved in the presence of guar gum using potassium persulphate as initiator. One set of gels has been made with N,N’-methylene-bis-acrylamide (MBA) as the crosslinking agent and another with MBA and Gluteraldehyde(GA) as crosslinking agents. The effect of using single and two crosslinking agents on the gel structure has been evaluated by studying the swelling behaviour of gels made with different amounts of crosslinking agents. The gels crosslinked with MBA alone exhibited 3-5 times higher swelling when compared to the gels with 2 crosslinkers. The kinetics of swelling has been studied and the swelling parameters have been evaluated


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