Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Effect of Dielectric constant on Protonation Equilibria of Glycylglycine in Aqueous Solutions of propylene glycol and Dioxan

Author(s): Mekonen Tirfu Zekarias, Belete Yilma Hirpaye and Gollapalli Nageswara Rao

Knowledge of the protonation constants of dipeptides is important and necessary for complete understanding of their physiochemical behaviour. In this study, the protonation constants of glycylglycine were studied in propylene glycol and dioxan-water mixtures (0 - 60% v/v) at 303.0 ± 0.1 K at an ionic strength of 0.16 M using pH-metric technique. The protonation constants were calculated with the computer program MINIQUAD75 and selection of the best fit chemical models is based on the statistical parameters. The effect of solvent on protonation constants was discussed based on electrostatic forces operating on the protonation equilibria. Distribution of species, protonation equilibria and effect of influential parameters on the protonation constants have also been presented.


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