Oral route of administration have wide acceptance up to 50-60% to total drug forms. Fast disintegrating drug delivery system has number of advantage such as faster onset of action, attractive elegance, ease of administration, manufacturing, storage and transport. In this study, an attempt has been made to study direct compression method, for formulation of fast disintegrating tablets of Isoniazid, an anti-tubercular drug in view of enhancing bioavailability for the treatment of oral tuberculosis. These formulations have sufficient hardness and can be manufactured by commonly used equipment. Prior to formulation the precompression parameters were characterized for flow properties and prepared formulations were evaluated for physico-chemical parameters, X-ray powder crystallography, Scanning Electron Microscopy and anti-tubercular activity. All four formulations possessed good disintegration properties with total disintegration time of 25 to 40 seconds. The effects of different superdisintegrants and process variables on drug release profile and disintegration property were evaluated and results revealed the better drug release with different superdisintegrants such as Ac-di sol, Explotab, Kollidon CL and Polyplastadone XL. SEM results showed the mechanical strength of the formulations affected the morphological changes after compression. Hence, it is evident from this study that fast dispersible tablets could be a promising delivery system for Isoniazid delivery with good mouth feel and improved drug availability with better patient compliance.