GET THE APP

Effect of internal standard on HPLC analysis of tablet dosage forms: An experimental study with statistical comparison | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Effect of internal standard on HPLC analysis of tablet dosage forms: An experimental study with statistical comparison

Author(s): Mustafa テδεツ津δづ「ツツ。elebier, Merve Nenni, Ayテδε「ツツヲテδづツクegテδεツ津δづつシl Doテδε「ツツ榲δづツクan, テδε「ツツ榲δづつーncilay Sテδεツ津δづつシslテδεツ津δづつシ and Sacide Altテδε「ツツ榲δづつアnテδεツ津δづつカz

The purpose of this study was to investigate the effect of internal standard on precision and accuracy of an HPLC method for the analysis of tablet dosage forms. Paracetamol was chosen as a model molecule and caffeine was used as an internal standard for this purpose. An experimental procedure was applied and a statistical comparison was performed to present the effect of IS on precision and accuracy for the quality control analysis. IS was added in a constant amount (5, 20 and 40 μg mL-1) into the samples and calibration curve and internal standard techniques were used to determine the amount of PA in tablet dosage forms. As it is known, using IS corrects the loss of analyte during sample preparation or sample inlet. The results for calibration curve and internal standard techniques were statistically evaluated and discussed. According to the results in our experimental conditions, the internal standard technique statistically affected the analysis results but did not improve the precision and accuracy


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry