Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Effect of Malva sylvestris L. extract on blood cell parameters in mice with Candida albicans Infection

Author(s): Shirin Hajyani, Mehrdad Modaresi and Mahboobeh Madani

Various parts of Malva sylvestris have different medicinal benefits including antimicrobial activity.. Sixty female mice were divided randomly in six groups (three experimental groups, Candida, placebo, and control groups) by free access to food and water. Experimental groups received aquatic extract of Malva sylvestris L. (50, 100 and 200 mg/kg) for 20 days every other day via injection in peritoneum. Candida group received 1×106 cfu/ml of Candida albicans suspension (once) and placebo group received sodium chloride 9%. Control group didn’t receive any injection. Main blood parameters including WBC, RBC, Hg, HCT, MCV, MCH, MCHC, PLT, lymphocyte, Neutrophil, eosinophil and Monocyte, were evaluated. Red blood cells, all blood parameters and WBC numbers were increased significantly in proportion to control group, in candida group but it was not different in doses groups lymphocytes and neutrophil percentage were increase and decreased in candida and 200 mg/kg significantly respectively. In general, M. sylvestris L. aquatic extract by controlling red blood cells, all blood parameters, and WBC in candida infected groups was effective in strengthening immune system in proportion to control.


PDF