Effect of nicotinic acetylcholine receptors polymorphism in Egyptian males with chronic obstructive pulmonary disease | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Effect of nicotinic acetylcholine receptors polymorphism in Egyptian males with chronic obstructive pulmonary disease

Author(s): Adel A. E. Nassar, Eman A. E. Badr, Maha Yousif, Shaimaa S. Soliman and Safa M. Saber

The major reinforcing component of tobacco smoke is Nicotine which acts through neuronal nicotinic acetylcholine receptors (nAChRs). It is a strong predisposing factor for the development of chronic obstructive pulmonary disease (COPD). The aim of this study was to evaluate the associations between single nucleotide polymorphism (SNP) of nAChRs rs1051730 and demographic (including smoking index and cigarette consumption per day ), physiologic and lab characteristics of Egyptian males with COPD. This study was conducted on 68 COPD smoker patients and 32 non-COPD smokers who were selected from Chest Department, Faculty of Medicine, Menoufia University during the period from October 2015 to January 2016. A blood sample was taken and a spirometry was performed. Genotyping was performed for nAChRs rs1051730 by SNP assay real time PCR methods. The distribution of nAChRs rs1051730 AA genotypes is more frequent in COPD patients with increase susceptibility to COPD by 5.19 fold. AA genotypes were also associated with higher smoking index and more cigarette smoking per day. Increase frequency of AA genotypes in patient’s heavy smokers as an indicator of nicotine dependence. The Nicotinic acetylcholine receptors (nAChRs) SNP rs1051730 AA genotype and A allele may influence the development of COPD but not its severity. AA genotype of rs1051730 may also have more influence in nicotine dependence.


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