In silico and in vitro DNA binding studies were carried out on silk worm DNA to determine the efficiency of 1,3,4-thiadiazoles (Th1-9) on Bombyx mori larvae during their 5th instar larval stage to increase the tensile strength, quality and quantity of biopolymer silk. These compounds were synthesised using ultrasonication method and supplied in ultra-dose as food supplement along with mulberry leaves to Bombyx mori and recorded the growth and other parameters of silkworm, cocoon parameters and mechanical testing of silk filament. Tensile Strength, elongation and quantity of the silk was higher in larvae fed with synthesised compound in comparison with control larvae. This increase in strength and quality was due to the strong binding interactions of thiadiazoles moiety with silk worm DNA which was confirmed by higher binding energy values showed in In silco studies and DNA binding assay results.
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