The effects on phospholipid large unilamellar vesicles of two flavonoid derivatives: S-5682 (mixture of 90% diosmin and 10% hesperidin) and troxerutin (7,3',4'-tris(O-(2-hydroxyethyl)) rutin) have been studied by using quasielastic light scattering (QLS) and Fourier transform infrared spectroscopy (FT-IR) techniques. The results of QLS show a decrease of the Young elastic modulus of the phospholipid bilayer in the presence of these drugs and an effect on its phase transition by shifting the transition point and by inducing a second step in the transition. The results of FT-IR indicate an interaction of the drugs with the bilayer essentially at the aqueous interface. This interaction is consistent with the effects observed by QLS.
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