GET THE APP

Efficient Method for the Synthesis of Fingolimod and Impurities | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

ilbet

süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey

Abstract

Efficient Method for the Synthesis of Fingolimod and Impurities

Author(s): Maruthi Raju N, Venkateswara Rao B, Siddaiah V

Fingolimod (1b) is an immunomodulating, United States Food and Drug Administration (USFDA) approved Active Pharmaceutical Ingredients (API), which is one of the best drugs available for the treatment of Multiple Sclerosis (MS). Fingolimod was synthesized in seven steps using cheapest commercially inexpensive raw material octanophenone which meets high yield and purity. While developing the process of Fingolimod, some related impurities were observed. These impurities were recognized as Heptyl PNP (2a), Octyl PNP (2b), Nonyl PNP (2c), Nitro heptyl (3a), Nitro octyl (3b), Nitro nonyl (3c), Heptyl (1a) and Nonyl (1c) impurities. The present work explains the synthesis of fingolimod, its impurities and their characterization.


PDF

rokettube brazzers

paper.io

agar io

wowcappadocia.com
cappadocia-hotels.com
balloon-rides.net

wormax io

Smok
Elektronik Sigara