GET THE APP

Efficient Method for the Synthesis of Fingolimod and Impurities | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Efficient Method for the Synthesis of Fingolimod and Impurities

Author(s): Maruthi Raju N, Venkateswara Rao B, Siddaiah V

Fingolimod (1b) is an immunomodulating, United States Food and Drug Administration (USFDA) approved Active Pharmaceutical Ingredients (API), which is one of the best drugs available for the treatment of Multiple Sclerosis (MS). Fingolimod was synthesized in seven steps using cheapest commercially inexpensive raw material octanophenone which meets high yield and purity. While developing the process of Fingolimod, some related impurities were observed. These impurities were recognized as Heptyl PNP (2a), Octyl PNP (2b), Nonyl PNP (2c), Nitro heptyl (3a), Nitro octyl (3b), Nitro nonyl (3c), Heptyl (1a) and Nonyl (1c) impurities. The present work explains the synthesis of fingolimod, its impurities and their characterization.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry