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Electrochemical sensor for the detection of mefenamic acid in pharmaceutical sample and human urine at glassy carbon electrode | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Electrochemical sensor for the detection of mefenamic acid in pharmaceutical sample and human urine at glassy carbon electrode

Author(s): Shikandar D Bukkitgara, Nagaraj P Shettia*, Deepti S Nayaka, Gangadhar B Bagehalli and Sharanappa T Nandibewoor

The electrochemical oxidation of mefenamic acid has been investigated by cyclic, linear sweep and differential pulse voltammetry in phosphate buffer of different pH range 3-11, at glassy carbon electrode. Cyclic voltammetric studies were performed in a wide range of sweep rates and various concentration of mefenamic acid. The effect of surfactant was studied. The anodic peak was characterized and the process was adsorption controlled. The linear relationship between peak current and the mefenamic acid concentration were studied using differential pulse voltammetric technique, for the quantitative determination of mefenamic acid. The linear response was obtained in the range of 8 x 10-5 to 2 x 10-3 M with detection limit of MFA 1.49 x 10-7 with good selectivity and sensitivity. Furthermore, the proposed method was applied to in-vitro determination of mefenamic acid in pharmaceutical sample, spiked human urine by adopting the differential pulse voltammetric technique.


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