This research aims to investigate the best gel formula of grapefruit ethanol extracts (Citrus maxima Murr.) with gelling agent combination durian seed gum and carboxy methyl cellulose (CMC). Durian seed gum was isolated with centrifuge and then combined with CMC-Na in five formulas. Evaluation material of topical gel that is its homogeneity, pH, stability testing, and irritation of the volunteers. All formula gel preparations its homogeneity, pH, stability, irritation, and the ability to moisturize the skin. Formula V with a comparison of durian seed gum and CMC-Na 3:2 is a good formula.
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