The present study investigates the anti-inflammatory activity in ethanolic extract of Coriandrum sativum. L using carrageenan induced paw edema in albino rats. The medicinal values of the Coriandrum sativum. L has been mentioned ancient literature as useful in disorders of inflammation. Dried leaves of Coriandrum sativum. L powdered and extracted with ethanol using shaker. The anti-inflammatory was done by carrageenan induced hind paw edema method using plethysmometer. Indomethacin used as a standard drug. For this activity test groups received Control, Standard Indomethacin (40mg/kg), Induced 1% Carrageenan (0.1 ml),ethanolic leaf extract of Coriandrum sativum L. in 200mg/kg and 400mg/kg.The anti-inflammatory activity is more effective in Group V Carrageenan induction with oral administration of Coriandrum sativum ethanolic leaf extract of 400mg/kg/i.p compared to Group IV Carrageenan is subcutaneously induced along with the oral administration of Coriandrum sativum ethanolic leaf extract of 200mg/kg/i.p.