Antimicrobial activities of novel synthesized pyridinium derivatives showed prospective broad spectrum antimicrobial effect. The synthetic compounds were examined using agar well and dilution method. The antimicrobial effect was measured and represented as minimum inhibitory concentration (MIC). Halogentated pyridinium derivatives showed significant antimicrobial effect with MIC values ranged from 7.5 μg/ml to 180 μg/ml aganist ATCC strains and clinically isolated gram positive and gram negative microbes. P-flouro-derivative (79) was the broadest antimicrobial agent with MIC value = 7.5 μg/ml against Strep. B. Although, S.aureus, B.subtilis and C.albican are the most sensitive microbes , P.auregenosa , P.mirabilis and K.pneumoniae are the most challenging one.
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