Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Evaluation of Antimicrobial and Antifungal Properties of New Chrysene-Phenothiazine Derivatives
Author(s): Alpesh T. Shiyani*, Suranjana V. Mayani and Navnath B. ShindeA novel series of Chrysene-Phenothiazine derivatives was synthesized via the Buchwald-Hartwig C-N coupling reaction using 6-bromochrysene and substituted phenothiazine derivatives. The reaction employed palladium catalysis under inert conditions with appropriate ligands and bases to achieve efficient N-arylation at the phenothiazine nitrogen. This strategy enabled the formation of C-N bonds between the polyaromatic chrysene core and electronically modified phenothiazine units, providing structurally diverse heterocyclic hybrids. All compounds were purified and characterized by ¹H NMR, ¹³C NMR and mass spectrometry to confirm the desired molecular architecture. Preliminary antimicrobial and antifungal screening was performed using the agar well diffusion method, indicating that halogenated analogues displayed better activity profiles. Overall, this work demonstrates the utility of Buchwald-Hartwig amination as a robust synthetic route for accessing polycyclic nitrogen-bridged heterocycles with potential bioactivity.
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Citations : 15261
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